Anna Reska Dissertation Titles

Dr. Reid’s research interests focus on the early detection and chemoprevention of lung and head and neck cancers, and the evaluation of genetic/epigenetic biomarkers of early lesions in high risk populations. Dr. Reid is active in steering the High Risk Lung Cancer Screening Clinic at Roswell, where high risk patients are screened with CT and a bronchoscopy that combines standard white light with autofluorescent imaging. She has experience with chemoprevention trials including wheat bran fiber, selenium. Currently, she directs two ongoing trials in lung cancer prevention at Roswell Park. One ongoing trial is testing a form of Vitamin D. Dr. Reid, in collaboration with Candace Johnson, PhD and Donald L. Trump, MD, has obtained NCI funding to conduct a phase I toxicity study and a randomized, placebo controlled phase II clinical trial to supplement high risk current and former smokers with confirmed premalignant lesions of the lung. In addition, Dr. Reid and Alex Adjei, MD, PhD, have received funding to use low doses of a therapeutic agent, erlotinib, in aerodigestive cancer survivors who are found to have premalignant lesions on screening. The patients will be given progressively lower doses of this agent to assess the effectiveness of treatment on genetic markers in the lung and to assess the level of toxicity at these low doses.

Dr. Reid is also heading an effort with the Dental and Head and Neck clinical team to screen high risk head and neck cancer patients with conventional white light and autofluorescent imaging. These screening efforts have led to the involvement in NCI-sponsored clinical chemoprevention trials using new agents for the prevention of progression of premalignant lesions. Dr. Reid is also involved in biomarkers studies of early oral lesions and the risk of progression to cancer.

RPCI Institutional Activities

12/2008 - Presenter, Touch Science Program. An outreach program to Greater Buffalo science teachers to provide information on careers for young people in cancer at RPCI.
2003 - Scientific Review Committee
2003 - Lung Disease Site Research Group, Co-Director
2003 - Lung Disease Site Research Group, Advisory Committee
2004 - Head and Neck Disease Site Research Group, Scientific Director
2004-2006 - Epigenetics Research Group
2005 - Alliance Development Grant Reviewer, Ad Hoc
2006-2009 - IT Advisory Committee
2006 - Quality Care Clinical Research Council
2006 - Translational Research Tissue Support Resource (TRTSR) Committee
5/2007 - Pharmacokinetics Advisory Committee
7/2007 - Clinical Research Feasibility and Prioritization Review (CRPC) Committee
2007 - Nursing Research Task Force
6/2008-2009 - Co-Chair, IT Focus Group
6/2008 - Biostatistics Steering Committee
9/2008 - Program Co-Director, Lung Cancer Symposium 2008, Niagara-on-the-Lake, September 5-7, 2008.
2008 - Prevention Steering Committee
2009 - CCSG Steering Committee
2009 - Director, Thoracic Product Line
2009 - Tissue Utilization Committee
2010 - NYS Cancer Center Leadership Committee, RPCI Representative
2011 - Co-Chair, Scientific Review Committee
2011 - Department of Medicine Faculty Mentoring & Development Task Force

Other Institutional Activities

1999-2000 - College of Public Health Phase I and II Implementation Committee on Educational, University of Arizona
1999-2000 - College of Public Health Education Integration Committee, University of Arizona
1999-2002 - Co-Director for R25 Cancer Prevention and Control Training Program involving the training of 4 pre- and 7 post-doctoral fellows, Arizona Cancer Center, Tucson AZ
2008 - Consultant, PEITC Trial in Lung Cancer, University of Minnesota.


Journal Peer Review

1999 - Cancer, Epidemiology, Biomarkers and Prevention (CEBP)
2002 - Nutrition and Cancer
2002 - Clinical Cancer Research
2002 - Cancer Research
2002 - American Journal of Clinical Nutrition
2003 - Oncology
2003 - Journal of Alternative and Complimentary Medicine
2003 - Trace Elements in Biology and Medicine
2006 - American Journal of Epidemiology
2007 - Archives of Internal Medicine
2007 - Annals of Epidemiology
2008 - Advisory Board Member, Trace Elements in Biology and Medicine
2008 - Cancer Prevention Research
2008 - Journal of Thoracic Oncology
2010 - Journal of Environmental Research and Public Health
2010 - Familial Cancer Journal

Grant Review Committee Member
Ad Hoc

2003-2006 - NCI Grant Reviewer, Subcommittee G- Education
4/2003 - NCI Grant Reviewer, Subcommittee E: PO1 Programs
6/2005 - NCI Grant Reviewer, Subcommittee E: PO1 Programs
2005 - AVON- P30 Supplemental Grants for Breast Cancer Biomarker Studies, Special Review Panel 
2007 - NCI- SPORE Review Panel, Adhoc
2007 - Institutional Alliance Grants, RPCI
6/2008 - NCI- Grant Reviewer, Subcommittee E: PO1 Programs
3/2011 - NCI- CCSG Grant Reviewer
10/2011 - NCI- CCSG Grant Reviewer

Grant Review Committee Member
Appointed Member

2006-2010 - NCI Grant Reviewer, Subcommittee G- Education, Permanent member.



2001 - Cancer Epidemiology Course, Smoking and Cancer: A Review of the Current Literature, University of Arizona, Tucson AZ.
2001 - Epidemiology Seminar, Smoking Assessment Questionnaire Validation Using Plasma Cotinine Levels, University of Arizona, Tucson AZ.
2003 - Cancer Epidemiology Course lecture on Clinical Trials and Aerodigestive Cancers, Social and Preventive Medicine, University at Buffalo.
2003 - Nutritional Epidemiology Course lecture on Dietary Intervention Trials, SPM, University at Buffalo.
2004 - Oncology for Scientists- The Burden of Cancer, September and Chemoprevention, March. RPCI.
2005 - Cancer Prevention and Control lecture on Laboratory Methods in Molecular Epidemiology, RPCI.
2006 - Cancer Prevention and Control Course- Lung Cancer Prevention, RPCI.
2006 - Cancer Pathology Course- Biomarkers of Premalignant Lesions of the Lung.
2007-2009 - Principles of Chemotherapy
2010 - Scientific Ethics Training Course, RPCI.
2010 - Cancer Prevention & Control Course; Epidemiology & Prevention of Aerodigestive Cancers
2011 - Oncology for Scientists- The Burden of Cancer, September, RPCI

Undergraduate/Master’s Students

2005 - Jennifer Frustino (MS Natural Sciences Program, RPCI), graduated May 2005.  Project title: “Levels of p16 Expression in the Buccal Cells of Non-Cancer and Former Cancer Patients with Varying Levels of Risk”. Role: Primary Faculty Advisor.

2005 - Julie Wojtaszczyk (MS Natural Sciences Program, RPCI), graduated August 2005.  Project title: “Levels of Cyclin D1 Expression in the Buccal Cells of Non-Cancer and Former Cancer Patients with Varying Levels of Risk”. Role: Primary Faculty Advisor.

2005 - Nathan Mahoney (MS Natural Sciences Program, RPCI), graduated May 2005.  Project title: “Evaluation of the Toxicity of Selenium Supplementation in a Clinical Trial”. Role: Faculty Committee Member.

2005 - Balazs Gerloczy, MD (Oncologic Surgical Pathology Fellowship), Committee member, completed fellowship May 2005.  Project title: “Inflammatory Cytokine Gene Polymorphisms in Lung Cancer Patients”. Role: Faculty Committee Member.

2007 - Rashsmi Pande, DDS (MS in Natural Sciences, RPCI), Graduated May 2007.  Project title: “Significance of Signet Ring Cells in the Prognosis and Outcome of Colorectal Cancer Patients”. Role: Primary Faculty Advisor.

2007 - Sandra Jacob, RN, BSN (NP student at Damen College, Amherst, NY), Graduated December 2007. Role: Faculty Committee Member.

2007 - Soumya Ramananda, BS (MS student in Natural Sciences, RPCI, Graduated May 2008).  Project Title: “Early Detection of Premalignant Lesions of the Oral Cavity with Autofluorescence”.  Role: Primary Faculty Advisor.

2008 - Patricia Zagst, BS (MS student in Natural Sciences, RPCI, Expected graduation- September 2008).  Project Title: “FDA Regulations for Chemopreventive Agents: Considerations of Toxicity and Efficacy”.  Role: Primary Faculty Advisor.

2008 - Rachel Kermis, (High school student intern from Nardin Private School, graduated June 2008).  Faculty mentor for project, “Identification of Risk Factors and HPV exposure in Base of Tongue Tumors”.  Poster presentation at the AHNS Meeting, San Francisco, CA, July 2008.

2008 - Jaclyn Orlando, (BS student from Buffalo State University, Graduated - December 2008). Mentor for final student project, “Incorporating Active Smoking Cessation Clinic in the Thoracic Program at RPCI”.

2010 - Anne Marie Parise, (MS in Natural Sciences, RPCI; Graduated– June 2011). Project Title: Assessment of High Risk Lung Cancer patients perception of chemoprevention.  Role: Primary Faculty Advisor.

2010 - Christopher Wilcox, MS in Natural Sciences, RPCI; Graduated – September 2011).  Project: Association of HPV presence in Head & Neck tumor outcomes. Role: Primary Faculty Advisor.

Dissertation Committees

2007 - Ravi Menezes, PhD, Epidemiology, SPM, SUNYUB, Graduation May 2007.  Role: Faculty Committee Member.
2007 - Darryl Somayaji, MS, RN, CCRC (PhD student, College of Nursing, University of Utah).  Dissertation topic: Negotiating participation to oncology clinical trials for African Americans: race, identity, power and barriers to health.  Expected graduation - December 2011.  Role: Faculty Committee Member.
2007 - Luke Peppone, PhD, Epidemiology, SPM, SUNYUB, Graduated May 2007.  Role:  Faculty Committee Member.
2008 - Ravi Menezes, Saxon Graham Award for Excellence in Epidemiology and Community Health
2008 - Vijay Jayaprakash, MBBS, PhD, Epidemiology, SPM, SUNYUB, Graduated- December 2008.  Role:  Primary Faculty and Dissertation Advisor.
2008 - Kanitsak Boonanantanasarn, DDS (PhD student in Oral Biology, SUNYUB. Graduation – June 2010, Role: Dissertation committee member.
2009 - Chukwumere Nwogu, MD, Thoracic Surgery (PhD student in Epidemiology, Cancer Pathology and Prevention, Roswell Park Cancer Institute.  Expected graduation - 2012. Role: Faculty Advisor and Dissertation Advisor).
2009 - Jennifer Frustino, DDS, (PhD student in Epidemiology, Cancer Pathology and Prevention, Roswell Park Cancer Institute. Expected graduation - 2012. Role: Faculty Advisor and Dissertation Advisor).
2010 - Ngozi Nwizu, DDS, (PhD student in Edipemiology, Cancer pathology and prevention, Roswell Park Cancer Institute.  Expected graduation – 2013. Role: Dissertation Advisor).

Postdoctoral Trainees

2008 - Mary Platek, R25 Postdoctoral Fellow, RPCI. Research program goals: To develop research investigating the role of nutrition and nutritional status on response to radiation and chemotherapy for head and neck cancer.  Current position: Assistant Professor at NYU, NY, NY. Role: Primary Mentor

2008 - Zahanira Peitri, R25 Postdoctoral Fellow, RPCI.  Research program goals: To develop research into the association tes and radon, on lung cancer risk in the greater Buffalo metropolitan area. Role: Secondary Mentor.

2010 - Jennifer Frustino, R25 Postdoctoral Fellow, RPCI. Research program goals: To access the diagnostic potential of autofluorescence in the oral cavity.


Completed Grants

7/96-6/99 - Project Coordinator (35%), A Study of Genetic Alterations and Recurrence in Colorectal Polyps Associated with Smoking, ADCRC (PI: DS Alberts, MD) (Total Costs: $442,021).

7/98-7/02 - Co-Director (55%), R25 Cancer Prevention and Control training Grant, NCI (PI: JR Marshall, PhD) (Total Costs: $3,539,303).

2/00-12/00 - Principal Investigator (5%), Selenium Levels Predict Adenoma Recurrence, Cancer Prevention and Control Research Award, Arizona Cancer Center Core Grant Supplement (Total Cost: $9,580). 

7/00-7/01 - Co-Investigator (10%) Colon Cancer Prevention Program Project, NCI (PI: David Alberts, MD) (Total Costs: $20,545,742).

7/00-7/02 - Co-Investigator (10%), Watchful Waiting, NCI (PI: James Marshall, PhD) (Total Costs: $576,310).

7/00-7/02 - Co-Investigator (10%), Negative Biopsy Phase III Trial of Selenium, NCI (PI: James Marshall, PhD) (Total Costs: $620,866).

7/00-8/05 - Co-Investigator (10%), Nutritional Prevention of Cancer, NCI (PI: James Marshall, PhD) (Total Costs: $275,000).

11/01-7/02 - Principal Investigator (15%), Lung Cancer Prevention with Selenium Supplementation, ADCRC (Total Costs: $390,113).

4/04-3/09 - Co-Investigator (20%), Lung Cancer Molecular Markers by Sex: An Intergroup Study, NCI- RO1 (PI: Christine Ambrosone, PhD), Total Costs: $3,746,750.  The major goals of this project are to investigate gender differences in lung cancer, by assessment of biomarkers in tissue and blood and risk factor data.

7/05-8/07 - Co-Investigator (5%) Periodontal disease and the Incidence of Oral Cancer, NCI-R03 (PI: Mine Tezal, PhD) (Total Costs: $100,000).

09/05-08/11 - Principal Investigator (20%), Calcitriol for Chemoprevention in Preinvasive Bronchial Epithelial Lesions, NCI- RO1. Total Costs: $2,400,000.  To test the use of Vitamin D (Calcitriol) in the prevention of progression of preinvasive bronchial epithelial lesions in a high risk former smoker cohort.

12/05-11/10 - Co-investigator (5%), Biomarkers for the Progression of Head and Neck SCC, NCI- RO1 (PI: Norma Nowak, PhD), Total Costs: $1,500,000.  To assess genetic changes in a series in the carcinogenic transformation that contributes to the formation of head and neck squamous cell carcinomas.           

04/08-03/10 - Co-Investigator (5%), NCI-R03 (PI: H. Zhao). DNA repair capacity and risk of pre-malignant lesions in the lung epithelium.  Total costs:  $100,000.  To investigate the repair capacity in patients with progressive and regression premalignant lesions in the lung.

Current Grants

09/08-08/11 - Co-Director (10%), Cancer Prevention and Control Training Program, NCI-R25 CA114101 (Marshall). The major goal of this program is to training post-doctoral fellows training in a trandisciplinary, translational program in cancer prevention and control.                                                                                                                                
11/06-12/11            Principal Investigator (15%), Stacey Scott ABRIEN Lung Cancer Registry, RPCI Alliance Funding, Total Costs: $1,000,000.

06/09-05/13 - Principal Investigator (20%).  A Phase I study of Erlotinib in Patients with premalignant lesions of the lung.  Total Costs: $1,255,573. LOI to NCI Phase I/II Contract with Northwestern University.  To evaluate multiple low doses of erlotinib for toxicity and efficacy in high risk aerodigestive cancer survivors.

07/09-09/11 - Co-Investigator (5%). Development of Blood Based microRNA Profile as a Biomarker of Lung Cancer, NCI-RO3 (PI: Santosh Parnaik).  Total Costs: $100,000.  To utilize stored blood in lung cancer and high risk screening controls to identify a profile of microRNA markers that will serve as biomarkers for lung cancer.

07/10-06/15 - Consultant (5%).  The UCLA – Boston University Lung Cancer Biomarker Development Laboratory, NIH/NCI-U01 (PI: Avrum Spria, MD, MSc). LOI to Boston University.  Total Costs: $355,858.  The major goal of this program is to develop and characterize new biomarkers and assays for the early detection of lung cancer through airway mRNA/microRNA profiling and proteomic profiling of blood.

09/11-09/16 - Co-Investigator/Consultant. Family Smoking Prevention and Tobacco Control Act National Longitudinal Study, NIDA/FDA (PI: Andrew Highland, MD). Total Costs: $4,402,474. The National Longitudinal Survey of Tobacco Use (NLSTU) will develop a cohort of nearly 38,000 adults and 7,000 adolescents who will provide baseline biospecimens and annual tobacco use survey data.

10/11-10/16 - PI on Local Subcontract (5%), Detection of Early Lung Cancer Among Military Personnel (DECAMP)”, DOD (PI: Avi Spria, MD).  Surveillance SCT and bronchoscopy in military centers and RPCI to identify biomarkers associated with lung nodules that progress to cancer.

12/11-08/14 - PI on Local Subcontract (10%), Benzo[a]pyrene Metabolism: Phenotyping and Genotyping", NCI- R01 (PI: Stephen Hecht, PhD).  Determining the metabolism of benzo[a]pyrene in current smokers by genotype in a high risk lung cancer cohort.

12/11-11/12 - Principal Investigator (5%), Assessment of Genomic Damage in Oral Lesions, RPCI Alliance Funding, Total funding $48,084. During the multi-year progression from normal cell to cancer, numerous genomic alterations arise in events ranging from single base mutations to gains or losses of entire chromosomes, resulting in massive alteration in cellular physiology.

Pending Grants

07/12-06/15 - Principal Investigator (5%), Whole Blood MicroRNAs as Biomarkers of Lung Cancer, Dept of the Army (USAMRAA) DOD (PI: Reid). The benefit of early lung cancer detection and limitations of current paradigms: Lung cancer is the most common cause of cancer-related mortality, accounting for an estimated 159,000 deaths in the United States in 2009.

07/12-06/16 - Co-Principal Investigator on Local Subcontract (10%), Molecular Determinants of Invasive Progression of Premalignant Lung Lesions, NIH (PI: Avi Spira, MD). Site will oversee and track the collection of the clinical data corresponding to the lung biopsy samples at RPCI through DECAMP network.


1999 - CPC Seminar Series, “Smoking and Adenomatous Polyp Characteristics: a Case-Case Analysis”, Arizona Cancer Center, April 7, 1999.

2000 - CPC Seminar Series, “Lung Cancer and Selenium Supplementation”, Arizona Cancer Center, September 20, 2000.

2001 - ASPO, “Reports of toxicity on long-term supranutritional selenium supplementation: an analysis of a clinical trial”, March 11-13, 2001, New York, NY. 

2001 - AACR, “Lung Cancer and Selenium Supplementation”, March 24-28, 2001. New Orleans, LA.

2002 - Society for Epidemiologic Research (SER), “Biomarkers for Lung Cancer Chemoprevention”, June 21, 2002. Palm Springs, CA

2003 - SELECT Trial Workshop for SWOG, “Reporting on the Nutritional Prevention of Cancer Trial”, San Diego, April 9, 2003.

2003 - Cancer Therapeutics Grand Rounds, “Lung Cancer Prevention with Selenium Supplementation”, RPCI, May 2003.

2003 - Medical and Surgical Fellows Lecture Series, “Chemoprevention: From Mice to Men”, RPCI, 2003.

2005 - Cancer Therapeutics Grand Rounds, “Selenium Supplementation and Vitamin E Status”, RPCI, February 2005.

2005 - Epidemiology Lecture Series, “Research Program in a High Risk Lung Cancer Cohort”, Memorial Sloan Kettering Cancer Center, New York, New York, September 2005.

2005 - University of Chicago, Chicago IL. “Lung Cancer Screening in High Risk Cohort: the Roswell Park Experience 1998 – 2005”. October 2005.

2005 - Roswell Park Cancer Institute, Buffalo NY. Cancer Therapeutics and Prevention Grand Rounds, “Calcitriol and Lung Cancer Prevention”, November 2005.

2006 - Symposium on Quality Health among Older Individuals:  What Should We Recommend? “Selenium and Cancer Prevention”, Nutrition and the Center for Healthy Aging, the Obesity Nutrition Research Center (ONRC) and the Department of Epidemiology at the University of Pittsburgh, May 2006.

2007 - Cancer Institute of New Jersey, Prevention Grand Rounds, “Selenium and Cancer”, May 2007.

2007 - Johns Hopkins University, Baltimore, MD “The Prevalence and Persistence of Premalignant Lung Lesions: Findings from a High Risk Cohort”.  November 9, 2007.

2008 - Johns Hopkins University, MD, Welch Center for Prevention, Epidemiology and Clinical Research Grand Rounds.  “Selenium and Cancer”.  March 19, 2008.

2009 - Arizona Cancer Center, Tucson AZ.  Cancer Prevention Grand Rounds.  “Lung Cancer Screening and Chemoprevention”.  February 4, 2009.

2009 - ASPO Career Development Workshop, Tampa, FL. “Approaching applications for funding from multiple agencies”, March 7, 2009.

2009 - Moffitt Cancer Center, Tampa, FL. Medical Grand Rounds. “Lung Cancer Screening and Chemoprevention at Roswell Park”, March 13, 2009.

2009 - University of Pittsburgh Cancer Institute, Pittsburgh, PA. “Lung Cancer Screening and Biomarkers”, April 28, 2009.

2010 - ASPO Career Development Workshop, Bethesda, MD. “Grant Writing: Overviews, Updates and Insights”, March 23, 2010.

2010 - University of California, Los Angeles (UCLA), Los Angeles, CA. “Lung Cancer Surveillance and Chemoprevention”, May 13, 2010.

2010 - Roswell Park Cancer Institute, Buffalo, NY. “Lung Cancer: A Few Facts That You Should Know”, March 24, 2010.

2010 - Buffalo Fire Department, Buffalo, NY.  In-Service Education Program, “Lung Cancer: What Fire Fighters Should Know”.  10 firehouse lectures from June- August, 2010.

2010 - Roswell Park Cancer Institute, Buffalo, NY. “Trends in Lung Cancer Epidemiology”. September 25, 2010.

2010 - AACR Frontiers in Prevention Meeting, Philadelphia, PA. “Oral Cancer Screening Using Autofluorescence”.  November 10, 2010.

2011 - Providence Hospital, Spokane, WA.  “Lung Cancer Screening: the Roswell Park Experience”.  March 16, 2011.

2011 - Roswell Park Cancer Institute, Buffalo, NY. Continuing Medical Education for Primary Care Practitioners: Lung Cancer. “Lung Cancer Epidemiology”.  March 19, 2011.

2011 - Roswell Park Cancer Institute, Buffalo, NY. Medical Grand Rounds. “Overview of the Results of the National Lung Cancer Screening Trial: Clinical Implications”. September 16, 2011.

2011 - Karmanos Cancer Institute, Detroit MI. Medical Grand Rounds, “Lung Cancer Surveillance”.  September 22, 2011.

2011 - James Cancer Center, Ohio State Medical Center, Columbus OH.  Cancer Control Program Seminar. “Bimodality Screening for Aerodigestive Cancers”. September 28, 2011.

2011 - Roswell Park Cancer Institute, Buffalo, NY.  Nursing Education Series. “Lung Cancer Epidemiology”, September 26, 2011.


2002 - London School of Hygiene and Tropical Medicine, “Results of a Clinical Trial of Wheat Bran Fiber”, April 2000.

2002- Schrauzer Symposium, “Selenium and Cancer Prevention”, Baden-Baden, Germany. October 2002.

2004 - University of Surrey Biochemistry Department Lecture Series, “Selenium and Prostate Cancer Chemoprevention”, Guilford, UK, Guilford, UK, July 2004.

2004 - University of Leeds Epidemiology Guest Lecture Series, “Selenium and Cancer Prevention”, Leeds, UK, July 2004.

2005 - Trace Elements in Medicine and Animals, “Vitamin E and Selenium Supplementation: Results from a Clinical Trial”, Coleraine, Ireland, June 2005.

2007 - International Association of Oral Oncology, “Autofluorescence Detection of Oral Malignancies”, Amsterdam, May 2007.

2007 - World Lung Cancer Conference, IASLC. “The Prevalence and Persistence of Premalignant Lung Lesions: Findings from a High Risk Cohort”. Seoul, Korea. September 2, 2007.

2008 - Princess Margaret Hospital, University of Toronto, ON.  “The Results of Screening High Risk Lung Cancer Patients with Multiple Modalities: the Roswell Park Experience”.  May 6, 2008.

2008 - Selenium: a Multifaceted Element and the Thyroid; a Satellite Meeting of the European Thyroid Association. Hotel Grande Bretagne, Athens, Greece. “Selenium Levels and Cancer Protection: What We have Learned from NPC Studies”. September 19, 2008.

2010 - Frontiers in Carcinogenesis and Cancer Prevention.  Reliance Life Sciences Institute, Mumbai, India.  Chairperson, Lung Cancer Prevention Session.  “Lung Cancer Prevention: Overview of the State of the Art”.  February 5-7, 2010.

2010 - Second Niagara Lung Cancer Symposium 2010.  Niagara-on-the-Lake, Ontario, Canada.  Program Co-Chair.   “Choosing the Optimal Populations for Prevention: Defining Risk and Designing Trials”. September 10, 2010.

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