What is quorum sensing and how can it be targeted for antimicrobial infections?
Are tumours addicted to oncogene activity?
An insight into cation-pi interactions involved in structure and signalling in the plasma membrane.
Manipulating pre-mrna splicing as a theraputic strategy
The role of cation-pi interactions in transmembrane signalling proteins
How can genomic data be used to understand cancer evolution and to assist with cancer therapy?
Telomeropathies: consider the contribution of telomere maintenance mechanisms to inherited genetic disease
Discuss the origin and biological significance of horizontal gene transfer in higher plants
Can we assign a function to 80% of the DNA in the human genome?
Why do endosymbiotic bacteria have small genomes?
The pathogenesis of Guillain-Barré syndrome: What is the evidence for molecular mimicry?
The role of T suppressor cells in inflammatory Rheumatoid Arthritis
New insights into the molecular basis of hereditary haemochromatosis
T -cells in the pathogenesis of Rheumatoid Arthritis
Does repeated exposure to malaria infection influence subsequent risk of morbidity?
What is the role of EBV in the pathogenesis of endemic Burkitt's Lymphoma?
Role of endothelial damage in diabetic nephropathy
Stem Cell Niches
The influence of sex hormones on the pathogenesis of SLE
Helicobacter pylori and gastric cancer
The role of the A-beta protein in the pathogenesis of Alzheimers Disease
Why might 'Dracunculus medinesis' become the first human parasite to be eradicated
Polycystic Ovary Syndrome - What is its pathophysiology
Does molecular mimicy account for the pathogenesis of multiple sclerosis
Immunological memory : T Cell subsets and their functions
The phosphoinositide pathway and cancer
Discuss the uses and mechanisms of action of SSRIs
Mechanisms underlying cocaine abuse and addiction
Corticotrophin-releasing factor system as a potential target to treat affective disorders
Ion channel pathophysiology
Pharmacological advances in the treatment of chronic wounds
Tics in Tourette Synrome: Investigating the role of cognition and volition
Pharmacotherapy versus cognitive therapy in depression
Are animals capable of mental time travel?
The nature and treatment of cognitive deficits in schizophrenia
Is evil innate?
Psychopharmacology versus cognitive therapy in depression
The concept of core cognitive deficit in schizophrenia
Physiology, Development and Neuroscience
Metabolic and circulatory adaptations enabling enhanced muscle growth in body builders
Glucocorticoids and the treatment of infant respiratory distress syndrome
The role of NGF in CNS injury
The neurobiology of placebo analgesia
Prenatal and postnatal consequences of nephron deficit
The relation of Guyton's model of the circulation to our understanding of cardiac failure
The role of thyroid hormones in fetal maturation of the CNS
The role of maternal diet in determining future susceptibility to type 2 diabetes and metabolic syndrome
Tympanic hearing in terrestrial vertebrates
Hypothyroidism: its long and short term effects on the fetus
The physiological risks of ultra-endurance events
Astrocytes in amyotrophic lateral sclerosis - friend or foe?
Targeting sleep for cognitive enhancement: a dream or reality?
How close are we to a treatment for spinal cord injury?
Does reciprocal altruism really occur in animals?
Mother infant relationships form the bedrock of all mammalian social behaviour
Are there genes for behaviour?
Hardwired or not? The role of neural activity in nervous system development.
What evidence indicates a co-evolution of insectivore bats and moths?
Is diversity the spice of life? Exploring the relationship between nature, biodiversity and psychological well-being
Transcriptional signature matching strategies in computational drug discovery and repositioning
History and Philosophy of Science
The ethics of enhancing human traits
Woman and medicine in early modern Europe
The history of the localisation of brain function, including the use of Fmri
Prenatal screening for spina bifida: ethical considerations
The ethics of global research funding
Human, Social and Political Sciences
Investigating the Validity of the Endurance Running Hypothesis
The Dual Perspectives of Service Users and Staff of Health & Social Care Provision to Homeless People with Problematic Substance Use in Manchester
Medicine, Ethics and Law
The ethics of saviour siblings
The withdrawal or witholding of life-prolonging treatment
Voluntary euthanasia: the ethical arguments
The ethical problems associated with stem cell research
Psychological and Behavioural Sciences
A Biopsychosocial Model of Gender Identity and Dysphoria
The PAP group offers a wide variety of interesting BSc and MSc thesis topics. The overview below gives an impression of what the different researchers of PAP have to offer to students. If your interest is with one of the themes and topics listed below, please feel free to directly approach the contact person of the respective topic. If you have a general interest in doing your thesis at the PAP group, please first contact the education coordinator, Dr Otto Hospes.
For opportunities to collaborate in concrete (ongoing) projects, please go to the regularly updated Wageningen University website: www.tip.wur.nl. You can find examples of completed theses here.
Theme 1: Governance of wicked problems: theories, concepts and methods
Sustainability, climate change, food security, human rights and social injustice are just a few examples of so-called “wicked problems”: societal problems that are not only characterized by sheer complexity but also by controversy on what is the problem and by disagreement on what is the legitimate authority and best governance arrangement to effectively with the problem.
Theme 2: Water governance
Many of today’s water issues, such as drought, availability, flooding, salinization or pollution are not only technical issues but demanding matters of governance. Most water challenges transcend administrative borders of states and include a wide variety of actors in decision making: citizens, NGO’s, scientists, business, governments, transnational organisations all have a say when it comes to water resource management.
Theme 3: Governance at the boundaries of climate, energy, agriculture, food and water
Food security, obesity or climate change are examples of highly fragmented societal issues. Sectoral policies and instruments only address part of the problem. A popular way of thinking about these fragmented problems is in forms of nexus: different sectors that are linked to the problem or that can contribute to finding a solution to the problem come together in search for ways to collectively solve the challenge.
Theme 4: Food system governance and the right to food
Sustainable production of food and the (right of) access to food are key principles in food system governance. Governance of food is seen as both a challenge and solution to food security. Current (inter)national institutional architectures have failed in producing equitable and just access to food and have been unable to democratise values in food security governance.
Theme 5: Global Governance for sustainability
Sustainability is high on the agenda of global public, business and civil society actors: the expected adoption of the Millennium Development Goals (2015-2030), the increased commitment of multinational agribusiness companies to zero-deforestation, and the call for new forms of public-private governance of sustainability, all signal this.
Theme 6: Informational governance
Governance of information has become one of the most relevant, complicated, multi-scale and controversial issues in today’s world as a result of increased capacities to collect, store and share information. A major challenge is to identify governance arrangments that can foster knowledge creation, learning and innovation and social networking but at the same time be responsive to societal concerns on totally free or fully controlled flows of information.
Theme 7: Public administration and policy: theories, methods, concepts
The study of public administration has a long and tradition. Over the years many theories, methods and concepts have been developed to analyse how governments steer around societal issues. This work is often explaining how governments work or ought to work in addressing societal issues,and how they collaborate or should collaborate with business and civil society actors.